Protein structure prediction from sequence

CASP is a blind assessment: sequences are released, structures are withheld until predictions are in. What was ceded is single-chain structure prediction from sequence at a level the field had pursued for fifty years; the AlphaFold Protein Structure Database then released predictions for most known proteins. Not ceded: experimental determination remains the ground truth, and complexes, dynamics, disordered regions and the effect of point mutations are still open problems. The 2024 Nobel Prize in Chemistry recognized the people who built the method.